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AVRU Publications

2009

Warrell, DA, Williams D.  2009.  Response to comment on: Failure of a new antivenom to treat Echis ocellatus snake bite in rural Ghana: the importance of quality surveillance. Trans. R. Soc. Trop. Med. Hyg..

2008

Williams, DJ, O'Shea M, Daguerre RL, Pook CE, Wüster W, Hayden CJ, McVay JD, Paiva O, Matainaho T, Winkel KD et al..  2008.  Origin of the eastern brownsnake, Pseudonaja textilis (Duméril, Bibron and Duméril) (Serpentes: Elapidae: Hydrophiinae) in New Guinea: evidence of multiple dispersals from Australia, and comments on the status of Pseudonaja textilis pughi. Zootaxa. 1703:47-61.

2007

Winkel, KD.  2007.  Treatment of the first known case of king cobra envenomation in the United Kingdom, complicated by severe anaphylaxis.. Anaesthesia. Correspondence Web Site, 20 Feb 2007. Download: winkel2007.pdf (128.24 KB)
Williams, DJ, Jensen SD, Nimorakiotakis B, Muller R, Winkel KD.  2007.  Antivenom use, premedication and early adverse reactions in the management of snake bites in rural Papua New Guinea.. Toxicon.  49(6) Download: williamsetal2007.pdf (172.89 KB)
Steuten, J, Winkel K, Carroll T, Williamson NA, Ignjatovic V, Fung K, Purcell AW, Fry BG.  2007.  The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK).. Toxicon. 50(8) Download: steutenetal2007.pdf (1.07 MB)
Nimorakiotakis, V.  2007.  How to treat: snakebite – part one. Rural Doctor. Nov 2007. Download: nimorakiotakis2007.pdf (1.45 MB)
Nair, DG, Fry BG, Alewood P, Kumar PP, Kini RM.  2007.  Antimicrobial activity of Omwaprin, a new member of Waprin family of snake venom proteins.. Biochem. J.. 402:93-104. Download: nairetal2007.pdf (688.06 KB)
Hobbins, PG, Winkel KD.  2007.  The forgotten successes and sacrifices of Charles Kellaway, director of the Walter and Eliza Hall Institute, 1923–1944.. Med. J. Aust.. 187:645-648. Download: hobbinswinkel2007.pdf (224.52 KB)
Tibballs, J, Winkel KD.  2007.  Envenomation syndromes. Rogers' handbook of pediatric intensive care.  

2006

Winkel, KD, Mirtschin P, Pearn J.  2006.  Twentieth century toxinology and antivenom development in Australia.. Toxicon. 47:738-754.
Williams, D, Wüster W, Fry BG.  2006.  The good, the bad and the ugly: Australian snake taxonomists and a history of the taxonomy of Australia's venomous snakes.. Toxicon. 47:919-930.
Tibballs, J.  2006.  Struan Sutherland - Doyen of envenomation in Australia.. Toxicon. 47:860-871.
Tibballs, J.  2006.  Australian venomous jellyfish, envenomation syndromes, toxins and therapy.. Toxicon. 47:830-859.
Pung, YF, Kumar SV, Rajagopalan N, Fry BG, Kumar PP, Kini RM.  2006.  Ohanin, a novel protein from king cobra venom: its cDNA and genomic organization.. Gene. 371(2):246-256.
Pearn, J, Winkel KD.  2006.  Toxinology in Australia's colonial era: A chronology and perspective of human envenomation in 19th century Australia.. Toxicon. 47:726-737. Download: pearnwinkel2006.pdf (541.69 KB)
Pawlak, J, Mackessy SP, Fry BG, Bhatia M, Mourier G, Fruchart-Gaillard C, Servent D, Menez R, Stura E, Menez A et al..  2006.  Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove catsnake) with bird-specific activity.. J. Biol. Chem.. 281(39):29030-29041.
Norton, RS, Winkel KD.  2006.  Toxinology in Australia - pioneers to frontiers.. Toxicon. 47:717.
Mirtschin, PJ, Williams, D. J. HB, Millar D, R.M. L, Jensen S, King I, Warusam J.  2006.  The latest additions to Australia's dangerous snakes - the Papuan black snake and the Papuan taipan.. Reptiles Australia. 2(6):12-15. Download: mirtschinetal2006.pdf (3.96 MB)
Kuruppu, S, Fry BG, Hodgson WC.  2006.  In vitro neurotoxic and myotoxic effects of the venom from the black whip snake (Demansia papuensis).. Clin. Exp. Pharmacol. Physiol.. 33(4):364-368.
Fry, BG, Vidal N, Norman JA, Vonk FJ, Scheib H, Ramjan SF, Kuruppu S, Fung K, Hedges SB, Richardson MK et al..  2006.  Early evolution of the venom system in lizards and snakes.. Nature. 439(7076):584-588.
de Pender, AM, Winkel KD, Ligthelm RJ.  2006.  A probable case of Irukandji syndrome in Thailand. J. Travel Med.. 13(4):240-243.

2005

Wüster, W, Dumbrell AJ, Hay C, Pook CE, Williams DJ, Fry BG.  2005.  Snakes across the Strait: trans-Torresian phylogeographic relationships in three genera of Australasian snakes (Serpentes : Elapidae : Acanthophis, Oxyuranus, and Pseudechis).. Mol. Phylo. Evol. 34(1):1-14. Download: wuesteretal2005.pdf (343.52 KB)
Winkel, KD, Tibballs J, Molenaar P, Lambert G, Coles P, Ross-Smith M, Wiltshire C, Fenner PJ, Gershwin LA, Hawdon GM et al..  2005.  Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: effects in human, rat and guinea-pig tissue in vitro and in pigs in vitro.. Clin. Exp. Pharmacol. Physiol.. 32(9):777-788. Download: winkeletal2005.pdf (640.08 KB)
Westhoff, G, Fry BG, Bleckmann H.  2005.  Sea snakes (Lapemis curtus) are sensitive to low-amplitude water motions.. Zoology (Jena). 108(3):195-200.
Tibballs, J.  2005.  Fresh frozen plasma after brown snake bite - Helpful or harmful? Anaesth. & Int. Care. 33(1):13-15.
Rogers, IR, Winkel KD.  2005.  Struan Sutherland's "Rationalisation of first-aid measures for elapid snakebite" - a commentary.. Wilderness Environ. Med.. 16(3):160-163.
Ramasamy, S, Fry BG, Hodgson WC.  2005.  Neurotoxic effects of venoms from seven species of australasian black snakes (Pseudechis): Efficacy of black and tiger snake antivenoms.. Clin. Exp. Pharmacol. Physiol.. 32(1-2):7-12.
Lumsden, NG, Fry BG, Ventura S, Kini RM, Hodgson WC.  2005.  Pharmacological characterisation of a neurotoxin from the venom of Boiga dendrophila (Mangrove catsnake).. Toxicon. 45(3):329-334.
Li, M, Fry BG, Kini RM.  2005.  Eggs-only diet: Its implications for the toxin profile changes and ecology of the marbled sea snake (Aipysurus eydouxii).. J. Mol. Evol. 60(1):81-89.
Li, M, Fry BG, Kini RM.  2005.  Putting the brakes on snake venom evolution: The unique molecular evolutionary patterns of Aipysuras eydouxii (Marbled sea snake) phospholipase A2 toxins. Mol. Biol. Evol. 22(4):934-941.
Kuruppu, S, Fry BG, Hodgson WC.  2005.  Presynaptic neuromuscular activity of venom from the brown-headed snake (Glyphodon tristis).. Toxicon. 45(3):383-388.
Fry, BG.  2005.  From genome to "venome": Molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins. Genome Res.. 15(3):403-420.
Barbaro, KC, Knysak I, Martins R, Hogan C, Winkel K.  2005.  Enzymatic characterization, antigenic cross-reactivity and neutralization of dermonecrotic activity of five Loxosceles spider venoms of medical importance in the Americas.. Toxicon. 45(4):489-499.

2004

Nevalainen, TJ, Peuravuori HJ, Quinn RJ, Llewellyn LE, Benzie JAH, Fenner PJ, Winkel KD.  2004.  Phospholipase A2 in Cnidaria. Comp. Biochem. & Physiol. B: Biochem. & Mol. Biol. 139(4):731-735.
McGain, F, Limbo A, Williams DJ, Didei G, Winkel KD.  2004.  Snakebite mortality at Port Moresby General Hospital, Papua New Guinea, 1992-2001. Med. J. Aust. 181(11-12):687-691.
Lumsden, NG, Fry BG, Kini RM, Hodgson WC.  2004.  In vitro neuromuscular activity of 'colubrid' venoms: clinical and evolutionary implications. Toxicon. 43(7):819-827.
Hogan, CJ, Barbaro KC, Winkel K.  2004.  Loxoscelism: Old obstacles, new directions. Ann. Emerg. Med. 44(6):608-624.
Fry, BG, Wüster W.  2004.  Assembling an arsenal: Origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences.. Mol. Biol. Evol. 21(5):870-883.
Cheng, AC, Winkel KD.  2004.  Antivenom efficacy, safety and availability: measuring smoke. Med. J. Aust.. 180(1):5-6.
Wickramaratna, JC, Fry BG, Loiacono RE, Aguilar M-I, Alewood PF, Hodgson WC.  2004.  Isolation and Characterisation at Cholinergic Nicotinic Receptors of a Neurotoxin from Venom of the Acanthophis Sp. Seram Death Adder. Biochemical Pharmacology. 68(2):383-394.
Chetty, N, Du A, Hodgson WC, Winkel K, Fry BG.  2004.  The In Vitro Neuromuscular Activity of Indo-Pacific Sea-Snake Venoms: Efficacy of Two Commercially Available Antivenoms. Toxicon. 44(2):193-200.

2003

Wickramaratna, JC, Fry BG, Hodgson WC.  2003.  Species-dependent variations in the in vitro myotoxicity of death adder (Acanthophis) venoms.. Toxicol. Sci.. 74(2):352-360.
Wickramaratna, JC, Fry BG, Aguilar MI, Kini RM, Hodgson WC.  2003.  Isolation and pharmacological characterisation of a phospholipase A2 myotoxin from the venom of the Irian Jayan death adder (Acanthophis rugosus). Brit. J. Pharmacol.. 138(2):333-342.
Tibballs, J, Kuruppu S, Hodgson WC, Carroll T, Hawdon G, Sourial M, Baker T, Winkel K.  2003.  Cardiovascular, haematological and neurological effects of the venom of the Papua New Guinean small-eyed snake (Micropechis ikaheka) and their neutralisation with CSL polyvalent and black snake antivenoms. Toxicon. 42(6):647-655.
Hodgson, WC, Eriksson CO, Alewood PF, Fry BG.  2003.  Comparison of the in vitro neuromuscular activity of venom from three Australian snakes (Hoplocephalus stephensi, Austrelaps superbus and Notechis scutatus): Efficacy of tiger snake antivenom.. Clin. Exp. Pharmacol. Physiol. 30(3):127-132.
Fry, BG, Wüster W, Ramjan SFR, Jackson T, Martelli P, Kini RM.  2003.  Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: evolutionary and toxinological implications.. Rapid Comm. Mass Spect. 17(18):2047-2062.
Fry, BG, Wüster W, Kini RM, Brusic V, Khan A, Venkataraman D, Rooney AP.  2003.  Molecular evolution and phylogeny of elapid snake venom three-finger toxins.. J. Mol. Evol. 57(1):110-129.
Fry, BG, Lumsden NG, Wüster W, Wickramaratna JC, Hodgson WC, Kini RM.  2003.  Isolation of a neurotoxin (alpha colubritoxin) from a nonvenomous colubrid: Evidence for early origin of venom in snakes. J. Mol. Evol. 57(4):446-452.
Winkel, KD, Hawdon GM, Fenner PJ, Gershwin L, Collins AG, Tibballs J.  2003.  Jellyfish Antivenoms: Past, Present, and Future. Journal of Toxicology. 22(1):115-127.
Fry, BG, Winkel DK, Wickramaratna JC, Hodgson W, Wuster W.  2003.  Effectiveness of Snake Antivenom: Species and Regional Venom Variation and Its Clinical Impact. Journal of Toxicology. 22(1):23-24.

2002

Winkel, KD, Hawdon GM, Ashby K, Ozanne-Smith J.  2002.  Eye injury after jellyfish sting in temperate Australia. Wilderness & Environ Med.. 13(3):203-205.
Tibballs, J, Monagle P.  2002.  Tiger snake envenomation and disseminated intravascular coagulation (DIC).. Pathology. 34(5):481-482.
Taylor, DM, Ashby K, Winkel KD.  2002.  An analysis of marine animal injuries presenting to emergency departments in Victoria, Australia. Wilderness & Environ Med.. 13(2):106-112.
Mirtschin, P, Tibballs J.  2002.  Obituary - Passing of Professor Struan Sutherland. Toxicon. 40(7):1075-1076.
McGain, F, Winkel KD.  2002.  Ant sting mortality in Australia. Toxicon. 40(8):1095-1100.
Fry, BG, Wickramaratna JC, Hodgson WC, Alewood PF, Kini RM, Ho H, Wüster W.  2002.  Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications.. Rapid Comm. Mass Spect.. 16(6):600-608.

2001

Winkel, KD.  2001.  Anaphylaxis associated with the same batch of tiger-snake antivenom - Comment. Med. J. Aust.. 174(11):609-610.
Winkel, KD.  2001.  Strychnine, ammonia and gunpowder for snakebite - the end of an era. Med. J. Aust.. 174(11):607.
Tibballs, J, Hawdon G, Winkel K.  2001.  Mechanism of cardiac failure in Irukandji syndrome and first aid treatment for stings. Anaesth. & Int. Care. 29(5):552.
Tibballs, J, Hawdon G, Winkel K.  2001.  Pressure immobilisation bandages in first-aid treatment of jellyfish envenomation: current recommendations reconsidered. Med. J. Aust.. 174(12):666.
McGain, F, Harrison JE, Winkel KD.  2001.  Wasp sting mortality in Australia: one further case.. Med. J. Aust.. 174(5):255-256.
Cheng, AC, Winkel KD.  2001.  Snakebite and antivenoms in the Asia-Pacific: wokabaut wantaim, raka hebou ("walking together"). Med. J. Aust.. 175(11-12):648-651.
Cheng, AC, Winkel KD.  2001.  Call for global snake-bite control and procurement funding. Lancet. 357(9262):1132-1132.
Young, AR, Pincus SJ.  2001.  Comparison of Enzymatic Activity from Three Species of Necrotising Arachnids in Australia:. Loxosceles Rufescens, Badumna Insignis andLampona Cylindrata. Toxicon. 39(2-3):391-400.

2000

Winkel, KD, Hawdon G, Carroll T.  2000.  Mis-diagnosis of brown snake bite? Crit. Care Resusc.. 2(2):161-2.
Winkel, KD.  2000.  Acute and recurrent skin ulceration after spider bite - In reply.. Med. J. Aust.. 172(6):304-304.
Wiltshire, CJ, Sutherland SK, Fenner PJ, Young AR.  2000.  Optimization and preliminary characterization of venom isolated from 3 medically important jellyfish: the box (Chironex fleckeri), Irukandji (Carukia barnesi), and blubber (Catostylus mosaicus) jellyfish.. Wilderness Environ. Med.. 11(4):241-250.
McGain, F, Harrison J, Winkel KD.  2000.  Wasp Sting Mortality in Australia. The Medical Journal of Australia. 173(4):198-200.

1999

Torres, AM, Wang XH, Fletcher JI, Alewood D, Alewood PF, Smith R, Simpson RJ, Nicholson GM, Sutherland SK, Gallagher CH et al..  1999.  Solution structure of a defensin-like peptide from platypus venom.. Biochem. J.. 341:785-794(Pt3).
Winkel, KD, Hawdon GM, Levick NR.  1999.  Pressure-Immobilisation First Aid For Neurotoxic Snake Bites. Annals of Emergency Medicine. 34(2):294-295.
Sutherland, SK.  1999.  Concern Over Choice of Antivenom For 'False King Brown Snake' Bites and a Plea For a Name Change. The Medical Journal of Australia. 170(4):187.
Sutherland, SK.  1999.  A Life-Threatening Anaphylactoid Reaction to Polyvalent Antivenom Despite Pretreatment. The Medical Journal of Australia. 170(2):92.
Winkel, KD.  1999.  Caution Regarding Bier's Block Technique For Redback Spider Bite. The Medical Journal of Australia. 171(4):220.
Pincus, SJ, Winkel KD, Hawdon GM, Sutherland SK.  1999.  Acute and Recurrent Skin Ulceration After Spider Bite. The Medical Journal of Australia. 171(2):98-102.
Harrington, T, Raven RJ, Bowe PC, Hawdon GM, Winkel KD.  1999.  Funnel-Web Spider (Hadronyche Infensa) Envenomation in Coastal South East Queensland. The Medical Journal of Australia. 171(11-12):651-653.
Cheng, A, Winkel K, Hawdon GM, McDonald M.  1999.  Irukandji-like Syndrome in Victoria. Australian and New Zealand Journal of Medicine. 29(6):835.

1998

Tibballs, J, D. W, Sutherland SK.  1998.  The effects of antivenom and verapamil on the haemodynamic actions of Chironex fleckeri (box jellyfish) venom.. Anaesth. & Int. Care. 26(1):40-45.
Bell, KL, Sutherland SK, Hodgson WC.  1998.  Some pharmacological studies of venom from the inland taipan (Oxyuranus microlepidotus). Toxicon. 36(1):63-74.
South, M, Wirth P, Winkel K.  1998.  Envenomation by a Juvenile Steatoda Spider Treated With Redback Spider Antivenom. The Medical Journal of Australia. 169(11-12):642.
Tibballs, J, Hawdon GM, Pincus SJ, Winkel KD.  1998.  Sever Tiger Snake Envenomation in a Wilderness Environment. The Medical Journal of Australia. 169(4):228-229.

1997

Hopkins, BJ, Hodgson WC, Sutherland SK.  1997.  An in vitro pharmacological examination of venom from the soldierfish Gymnapistes marmoratus.. Toxicon. 35(7):1101-1111.
Levick, N, Winkel K, Smith G.  1997.  European Wasps: An Emerging Hazard. The Medical Journal of Australia. 167(11-12):650-651.

1996

Hopkins, BJ, Hodgson WC, Sutherland SK.  1996.  Evidence for adrenergic and tachykinin activity in venom of the stonefish (Synanceja trachynis).. Toxicon. 34(5):541-554.
Donovan, GR, Street MD, Tetaz T, Smith AI, Alewood D, Alewood P, Sutherland SK, Baldo BA.  1996.  Expression of jumper ant (Myrmecia pilosula) venom allergens: Post-translational processing of allergen gene products.. Biochem Mol. Biol. Internat.. 39(5):877-885.

1995

Sutherland, SK.  1995.  Pressure immobilization for snakebite in Southern Africa remains speculative.. S. Afr. Med. J.. 85(10):1039-1040.
Sutherland, SK, Leonard RL.  1995.  Snake Bite Deaths in Australia 1992-1994 and a Management Update. The Medical Journal of Australia. 163(11-12):616-618.

1994

Sutherland, SK.  1994.  Antiovenom research in Australia.. Med. J. Aust.. 161(1):48-50.
Sutherland, SK.  1994.  The pressure immobilization technique.. Med. J. Aust.. 161(11-12):700-701.